Mark‌ ‌the‌ ‌letter‌ ‌A,‌ ‌B,‌ ‌C,‌ ‌or‌ ‌D‌ ‌on‌ ‌your‌ ‌answer‌ ‌sheet‌ ‌to‌ ‌indicate‌ ‌the‌ ‌word(s)‌ ‌CLOSEST‌ ‌in‌ ‌meaning‌ ‌to‌ ‌the‌ ‌underlined‌ ‌word(s)‌ ‌in‌ ‌each‌ ‌of‌ ‌the‌ ‌following‌ ‌questions: 

The recent medical breakthrough was the culmination of many long years of experimentation.

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